01
Inhalation
Aromatic molecules interact with olfactory and trigeminal receptors, influencing neural and emotional responses.
Key Pathways:Olfactory (CN I)
Trigeminal (CN V)
NATURE. SCIENCE. HUMAN WELL-BEING.
Bio-Responsive
Ingredients
From Nature’s Molecules
to Human Possibilities
Bio-responsive ingredients are naturally
derived molecules that interact with
sensory receptors, neural pathways,
and biological targets, offering opportunities
for innovative applications in fragrance,
food & beverage, personal care and
beyond.
REAL MOLECULES.
REAL RESPONSES.
A BRIGHTER TOMORROW.
- SENSORY
PERCEPTION - NEURAL
RESPONSE - PHYSIOLOGICAL
EFFECTS - HUMAN
WELL-BEING
- LIGAND (MOLECULE)
- RECEPTOR
- CELL MEMBRANE
- SIGNAL TRANSDUCTION
(INTRACELLULAR)
Three Exposure Routes
One Ingredient. Multiple Opportunities.
02
Oral Intake
Molecules interact with oral and gastrointestinal sensors, with potential systemic effects.
Key Pathways:Taste Receptors
Gut Epithelium • ENS
03
Topical Application
Molecules interact with skin receptors, supporting cutaneous and neuro-skin responses.
Key Pathways:Cutaneous Receptors
Neuro-Skin Axis
The Bio-Responsive Framework
MOLECULE
Naturally derived
bioactive compoundRECEPTOR
Interaction with
biological targetsSIGNALING
Transduction via neural
or cellular pathwaysRESPONSE
Physiological effects
and well-being
NATURAL SOLUTIONS FOR A MORE VIBRANT LIFE.
SCIENCE TODAY, POSSIBILITIES TOMORROW.
The A&S Approach to Bio-Responsive Research
From Product Thinking
to Human Response Thinking
A&S studies how ingredients interact with sensory and biological systems—and how those interactions can be translated into meaningful, measurable applications.
MOREA Broader Research Perspective
Product-Led Questions
What is the ingredient?
What function
does it offer?
How is performance
measured?
Where can it be applied?
A&S Human-Response
Questions
How is it sensed
by the body?
Which mechanisms
are involved?
What biological
responses occur?
What functional
outcomes can be
supported?
What A&S Brings Together
Sensory Science
Perception and
sensory interfaces
Life Science
Biological pathways
and cellular responses
Evidence & Validation
Measurable responses
and functional outcomes
Application
Development
Translating research
into real-world solutions
SCIENCE FOR A BRIGHTER TOMORROW
Exploring the Broader Potential of Bioactive Compounds
From Natural Sources to Bio-Responsive Potential
A&S explores natural ingredients, active compounds, and selected aroma molecules to understand their biological interactions and functional potential.
Our ScienceOur Ingredient Research Scope
EXPLORING NATURE. UNLOCKING POTENTIAL.
Natural
Ingredients
Botanical
Extracts
Aroma
Molecules
Functional
Bioactives
Biotechnology-
Derived Actives
Representative Bio-Responsive Aroma Candidates
NATURAL MOLECULES. MEANINGFUL POTENTIAL.
NATURE × SCIENCE × HUMAN WELL-BEING.
Bio-Responsive
Ingredients
Nature-Derived Molecules. Purposeful Human Response.
BOTANICAL INTELLIGENCE
FOR A HEALTHIER TOMORROW
Olfactiva™
Olfactory Well-Being
BREATHE
BALANCE
BE WELL
MORE DETAILS
Travion™
Skin Barrier & Comfort
CALM
PROTECT
COMFORT
MORE DETAILS
Meraxyl™
Sensitive Skin
SOOTHE
BALANCE
RENEW
MORE DETAILS
Cortiva™
Skin Longevity
DEFEND
STRENGTHEN
REJUVENATE
MORE DETAILS
Melacor™
Brightening & Tone
CLARIFY
EVEN
RADIATE
MORE DETAILS
Morphagen™
Hair Growth & Vitality
ACTIVATE
NOURISH
THRIVE
MORE DETAILS
Chromagen™
Hair Color Vitality
PIGMENT
BALANCE
REVITALIZE
MORE DETAILS
01 · A&S Olfactiva™ Ingredient & Olfactory Interface
Nature × Science × People
Olfactiva™
Proprietary
bio-responsive
ingredient
Bio-responsive properties
- Naturally derived
- Selective receptor activation
- Adaptive interaction with biological systems
- Potent at low concentrations
- Synergistic with endogenous physiology
From Scent to Well-Being
Olfactiva™ ingredient molecules interact with olfactory receptors, initiating physiological responses via the olfactory system.
Natural
Targeted
Bio-responsive
02 · Olfactory Activation & Bio-Responsive Properties
Small molecules. Meaningful impact.Olfactory Activation
Inhaled odor molecules from bio-responsive ingredients reach the olfactory epithelium, initiating olfactory signaling pathways.
- Naturally derived
- Selective receptor activation
- Adaptive interaction with the body
- Effective at low doses
- Synergistic with endogenous systems
Well-being through nature’s signals
01 · Olfactiva™ Ingredient Molecules & Olfactory Pathway
Nature × Science × People
The Olfactory Pathway
Olfactory epithelium(olfactory mucosa)- Olfactory sensory neurons(olfactory nerve)
- Olfactory bulb
- Olfactory cortex
Olfactory ensheathing cellsLocal immune support
Brain Network
- Hypothalamus
- Amygdala
- Hippocampus
- Thalamus
- Prefrontal cortex
Thalamus Prefrontal cortex
reciprocal interaction
Interconnected brain regions translate scent into memory, emotion and behavior.
02 · Brain Regions & Functional Processing
Well-being through nature’s signalsHypothalamus
Integrates olfactory signals with autonomic and endocrine functions.
Amygdala
Processes emotional and affective aspects of olfactory information.
Hippocampus
Links olfactory input to memory and learning.
Thalamus
Relays and integrates olfactory information with other sensory systems.
Prefrontal cortex
Supports conscious perception, attention and higher-order olfactory processing.
01 · Olfactiva™ Bio-Responsive Signaling
From molecular signals to systemic responsesOlfactiva™ Bio-Responsive Ingredients
Neurotransmitter &
Neuroendocrine Signaling
- Catecholamines
- Glucocorticoids
- Serotonin
- GABA
- Cortisol
Potential neurogenesis /
sphingomyelinase–ceramide signaling
Autonomic & Central
Nervous System Regulation
- CNS modulation
- Autonomic balance (SNS / PNS)
- Neural plasticity
- Pain sensitivity modulation
Immune & Inflammatory
Modulation
- Cytokine balance
- Immune cell regulation
- NF-κB pathway modulation
- Inflammation resolution
Metabolic & Endocrine
Regulation
- Endocrine balance
- Glucose metabolism
- Lipid metabolism
- Insulin sensitivity
- Energy balance
02 · Potential Relevance & Well-Being Outcomes
From physiological signals to a healthier tomorrowPotential Clinical Relevance
- Mood disorders
- Stress-related dysfunction
- Sleep disturbance
- Inflammation
- Metabolic imbalance
Potential Well-Being & Health Outcomes
- Emotional balance
- Stress resilience
- Reduced anxiety
- Mood support
- Sleep quality
- Cognitive function
- Fatigue reduction
- Pain sensitivity modulation
- Immune balance
- Metabolic homeostasis
01 · A&S Travion™ Ingredient System
Five bio-responsive ingredientsTravion™
Company-developed proprietary
bio-responsive aroma ingredient system
Linalool
Floral · Calming
Soothing and calming aroma profile
Essential oilCitron EOs
Citrus · Refreshing
blendRefreshing multi-monoterpene composition
Limonene
Citrus · Uplifting
Uplifting antioxidant action
α-Terpineol
Herbal · Soothing
Herbal soothing profile
Terpinen-4-ol
Herbal · Balancing
Herbal balancing profile
02 · A&S Travion™ Support Profile
One system. Multiple benefits.Travion™ Supports:
TRPV1 / TRPA1 modulation
Helps reduce neurogenic inflammation
Supports immune balance
Supports barrier integrity
Supports skin comfort & well-being
02 · A&S Travion™ Mechanism of Action
Five bio-responsive ingredientsLinalool
Soothing & calming
Floral · Calming
- 1
Reduced neural signaling
- 2
Decreased neurotransmitter release
- 3
Maintained nerve-calming state
Citron EOs
Refreshing multi-monoterpene composition
Citrus · Refreshing
- 1
Synergistic receptor interaction
- 2
Broader binding potential
- 3
Enhanced efficacy through composition
Limonene
Uplifting antioxidant action
Citrus · Uplifting
- 1
TRPV1 modulation
- 2
Oxidative-stress scavenging
- 3
Reduced inflammatory signaling
α-Terpineol
Herbal soothing
Herbal · Soothing
- 1
Sensory-neuron desensitization
- 2
Enhanced anti-nociceptive effect
- 3
Reduced substance P release
Terpinen-4-ol
Herbal balancing
Herbal · Balancing
- 1
Immune-cell modulation
- 2
Reduced mast-cell degranulation (histamine release)
- 3
Support for immune balance
01 · Exposome & Epidermal Response
Environment meets skin biologyExposome – Skin Stressors
UV / UVB
Heat
Chemicals
Pollution
Microbiome dysbiosis
Stress
Epidermis (Keratinocytes)
Travion™ inhibits TRPV1 and TRPA1
Travion™
TRPV1 Activity
TRPA1 Activity
Keratinocyte response
(restored)
Strong dual inhibition
Neuroimmune Signals (Reduced)
Acetylcholine
(ACh)
Histamine
Inflammatory cytokines
02 · Downstream Response & Barrier Integrity
One pathway. Healthier-looking skin.Downstream Outcomes (Improved)
Skin inflammation & neurogenic reactivity
Immune balance & skin comfort
Barrier recovery & resilience
Stress Axis (Modulated)
cHPA Axis / Cortisol
Enhanced Skin Barrier Integrity
- Stronger stratum corneum
- Reduced permeability
- Better barrier function
- Resilient, healthy-looking skin
A&S Travion™ · Long-Term Skin Benefit Profile
Six complementary benefit areas
Reduced inflammation
Helps soothe and calm reactive skin.
01 · Inflammation
Immune balance
Supports a balanced and adaptive skin immune response.
02 · Immune Balance
Calmer skin
Helps reduce visible redness and sensitivity.
03 · Calmer Skin
Barrier support
Strengthens skin barrier for enhanced protection.
04 · Barrier Support
Reduced stress-related skin discomfort
Helps buffer the impact of stress on the skin.
05 · Stress-Related
Improved skin comfort and resilience
Promotes healthy-looking, comfortable, and resilient skin.
06 · Comfort & Resilience
01 · KEY AROMA BIO-RESPONSIVE INGREDIENTS
MERAXYL™Meraxyl™
Company-developed proprietary bio-responsive aroma ingredient system
Selected natural aroma compounds with bio-responsive properties to help support sensitive skin.
Thymol
A natural monoterpene compound with herbal origin, known for its purifying properties.
Rosmarinic acid
A natural polyphenol compound with antioxidant properties, widely found in rosemary.
02 · BIO-RESPONSIVE SUPPORT FOR SENSITIVE SKIN
MERAXYL™Meraxyl™ Supports
- Sensitive skin modulation
- Helps reduce mast-cell activation
- Supports immune balance
- Helps calm itch-associated signaling
- Supports skin comfort & well-being
From natural aroma compounds to more resilient skin
SCIENCE
NATURE
SKIN WELL-BEING
02 · DUAL-PATHWAY NEUROIMMUNE MECHANISM
MERAXYL™A Dual-Pathway Neuroimmune Mechanism
Thymol — Sensory Nerve Pathway
Thymol
Agonists:
heat · capsaicin · low pH · ROS
Thymol modulates the TRPV1 binding site
- Reduced Ca2+ / Na+ influx
- Reduced neuronal depolarization
Rosmarinic Acid — Mast-Cell Pathway
Rosmarinic acid
Agonists:
substance P · C48/80 · C3a
Rosmarinic acid modulates MRGPRX2 activation
- Reduced G-protein / PLCγ signaling
- Reduced Ca2+ mobilization
- Reduced NF-κB signaling
03 · SYNERGISTIC MODULATION FOR SENSITIVE SKIN
MERAXYL™Synergistic Modulation for Sensitive Skin
- Thymol helps calm itch-associated sensory signaling.
- Rosmarinic acid helps reduce mast-cell activation and inflammatory mediator release.
- Together, they support neuroimmune cross-talk balance, skin comfort & well-being.
01 · EXPOSOME STRESSORS & EPIDERMAL ACTIVATION
MERAXYL™Exposome — Sensitive Skin Stressors
Daily environmental stressors can activate epidermal receptors and trigger skin sensitivity.
- Heat
- Chemicals
- Microbes
- UVB
- Stress
Epidermis
(Keratinocytes)
TLR TRP family
MRGPRX202 · BIO-RESPONSIVE MODULATION & SKIN COMFORT
MERAXYL™Bio-Responsive Modulation
Meraxyl™ helps modulate key signaling pathways to reduce mast-cell reactivity and support calmer, more comfortable skin.
Meraxyl™
Gα
MRGPRX2Ca2+
NF-κB
Effector Mediator System
- Degranulation
- Cytokines
- Chemokines
- Skin inflammation
- Immune response
- Itch
- Allergies / sensitivity
Calmer Sensitive Skin. Improved Comfort.
- Reduced mast-cell reactivity
- Better skin comfort
- Lower inflammatory signaling
- Support for sensitive skin resilience
01 · A&S Cortiva™ Ingredient System
Nature × Science × People
Cortiva™
Company-developed proprietary
bio-responsive aroma ingredient system
Science
Inspired
by Nature
Key Aroma Bio-Responsive Ingredients
1,8-cineole (eucalyptol)
Helps support a clear, balanced skin environment.
β-pinene
Helps refresh and revitalize stressed, sensitive skin.
Thymol
Helps calm and purify sensitive skin.
02 · A&S Cortiva™ Support Profile
Cortiva™ Supports:
- Helps inhibit high acetylcholine (ACh) levels
- Supports stress-induced cortisol modulation
- Supports dermal homeostasis
- Helps reduce collagen lossPreserves collagen integrity and elasticity
- Helps prevent wrinkle formationImproves skin smoothness and resilience
collagen lossStronger collagen
networkFewer wrinkles
& fine lines
Cortiva™
Nature × Science × People
β-Pinene–Linked Dual-Pathway Modulation
Science
Inspired
by Nature
01 · Acetylcholine-Related Signaling
Elevated ACh-related signaling
β-Pinene–linked modulation
Helps reduce excessive neural activation
Supports a calmer cutaneous signaling environment
Neural Signaling Balance
02 · Cortisol–GR Stress Signaling
Stress-associated cortisol signaling
β-Pinene–linked modulation
Supports balanced GR-related responses
Helps limit stress-associated inflammatory signaling
Stress-Response Balance
Result: More Resilient-Looking Skin
Stressed / Aged-Looking Skin
- Inflammatory cues more active
- Disorganized collagen structure
- Reduced fibroblast activity
- More visible wrinkles and fine lines
More Resilient-Looking Skin
- Reduced inflammatory cues
- More organized collagen structure
- Supported fibroblast activity
- Smoother-looking skin with fewer fine lines
03 · Supporting Skin Resilience
Supporting Skin Resilience
Helps maintain a balanced immune microenvironment
Supports collagen integrity and dermal homeostasis
Helps reduce the appearance of wrinkles and fine lines
Together, these pathways support smoother-looking, more resilient skin.
01 · Exposome Stressors & Epidermal Response
Exposome — Sensitive Skin Stressors
Heat- Chemicals
- Microbes
- UVB
- Stress
Epidermis
(Keratinocytes)
Cortiva™
Inhibits high acetylcholine (ACh) levels
POMC
Acetylcholine (ACh)
02 · Dermal Signaling & Visible Anti-Aging Benefits
Dermal Bio-Responsive Modulation
Dermis
(Fibroblasts)
Cortisol
Glucocorticoid receptor (GR)
MMP1
Fibroblast growth
IGF-1
Muscle contraction
Collagen
Parasympathetic
Reduced collagen loss
Prevention of wrinkle formation
Nature × Science × People
A&S Cortiva™ · Long-Term Skin Benefit Profile
Six benefit areas for skin comfort, balance, and resilience.
Science
Inspired
by Nature
Reduced stress-related skin sensitivity
Helps calm elevated acetylcholine (ACh) signaling for less reactive skin.
01Skin Sensitivity
Balanced stress signaling
Helps modulate stress-related skin responses for calmer skin balance.
02Stress Signaling
Stronger dermal homeostasis
Supports dermal balance and overall skin resilience.
03Dermal Homeostasis
Reduced collagen loss
Helps preserve collagen and skin elasticity.
04Collagen Support
Fewer wrinkles & fine lines
Helps reduce wrinkle formation and improve smoothness.
05Wrinkle Reduction
Improved skin comfort & resilience
Supports healthier-looking, more resilient skin over time.
06Comfort & Resilience
Skin Comfort · Dermal Homeostasis · Collagen Preservation · Well-Being
01 · A&S Melacor™ Ingredient System Nature × Science × Radiant Skin
Melacor™
Company-developed proprietary bio-responsive ingredient system
Five aroma bio-responsive ingredients in Melacor™
Carvacrol
HerbalClarifying
Carvone
FreshBalancing
Thymol
HerbalPurifying
β-Thujaplicin (Hinokitiol)
WoodyBrightening
Limonene
CitrusUplifting
02 · A&S Melacor™ Support Profile
Melacor™ Supports:
- Supports melanogenesis modulation
- Helps reduce excess melanin formation
- Supports brighter-looking skin
- Helps improve tone clarity
- Supports a more even complexion
Brighter skin today. Brighter tomorrow.
Melanogenic Signaling Modulation
Helps reduce excessive melanogenic signaling
Melacor™-linked modulation supports balanced melanogenic signaling through its five-component ingredient system.
Tyrosinase Activity Modulation
β-Thujaplicin (Hinokitiol)-linked inhibition, with additional component synergy, helps reduce excess melanin synthesis.
03 · Inflammation-Linked PIH Support
Thymol-linked inflammatory-pathway modulation helps reduce excessive cytokine signaling and limit inflammation-associated melanocyte stimulation.
Supporting a brighter, more even-looking complexion
- Supports balanced melanogenic signaling
- Helps regulate tyrosinase-associated melanin synthesis
- Supports a calmer inflammatory environment
- Helps improve tone clarity and evenness
Three complementary pathways support controlled pigment formation and post-inflammatory tone recovery.
Melacor™ complex: Carvacrol · Carvone · Thymol · β-Thujaplicin (Hinokitiol) · Limonene
01 · Skin Stress Triggers & Melanocyte Activation
Skin Stress Triggers (Exposome)
Environmental and internal skin stress signals activate the POMC/α-MSH pathway.
02 · Melanogenesis Modulation & Skin Brightening
Melanogenesis Modulation
Melacor™ helps inhibit tyrosinase activity and supports controlled melanin production for a more even skin tone.
Skin Brightening Efficacy
- Visible reduction of excess pigmentation
- Brighter, more even-looking complexion
- Healthier-looking, more radiant appearance
A&S Melacor™ · Long-Term Skin Benefit Profile
Brighter-Looking Skin
Helps improve skin radiance and clarity.
01Skin radiance
More Even Skin Tone
Supports a more uniform-looking complexion.
02Even skin tone
Reduced Visible Pigmentation
Helps reduce the look of excess melanin-related darkening.
03Pigmentation
Tyrosinase Modulation
Supports balanced melanin production pathways.
04Tyrosinase
Clearer Complexion
Helps promote a cleaner, fresher skin appearance.
05Complexion clarity
Skin Tone Refinement
Supports smoother, brighter, more refined-looking skin tone.
06Tone refinement
01 · A&S Morphagen™ Ingredient System
Visible science · Real beauty
Morphagen™
Company-developed proprietary bio-responsive ingredient system
Seven aroma bio-responsive ingredients in Morphagen™
Patchouli Alcohol
Herbal · Activating
α-Terpineol
Herbal · Revitalizing
Cedrol
Woody · Strengthening
Thuja orientalis
Herbal · Follicle-supporting
Rosemary
Herbal · Stimulating
β-Caryophyllene
Spicy · Balancing
Limonene
Citrus · Refreshing
02 · A&S Morphagen™ Support Profile
Science for healthier hair
Morphagen™ Supports:
- Supports OR2AT4 activation
- Supports SHH / GLI signaling
- Helps elevate cAMP response
- Supports Wnt / β-catenin activity
- Supports healthy hair cycling
- Supports hormonal balance and scalp support
A&S Morphagen™
Science for healthier hair
How Morphagen™ Supports Hair & Follicle Vitality
Seven complementary bio-responsive pathways working together for healthier, stronger-looking hair.
Patchouli Alcohol
OR2AT4 / cAMP
- OR2AT4-linked activation
- Supports cAMP-associated signaling
- Supports pathways associated with healthy hair cycling
Growth-signaling support
α-Terpineol
Androgen-pathway support
- 5α-reductase-linked modulation
- Helps limit excessive DHT-associated signaling
- Supports follicle maintenance
Hormonal-pathway balance
Cedrol
Structural anchoring
- Supports extracellular-matrix organization
- Supports collagen- and laminin-associated structure
- Supports keratin expression and follicle anchoring
Follicle-structure support
Thuja orientalis
Wnt / β-catenin
- Wnt/β-catenin-linked signaling
- Supports dermal papilla growth-factor activity
- Supports healthy anagen-phase signaling
Hair-cycle support
Rosemary
Scalp microenvironment
- Supports scalp microcirculation
- Supports nitric-oxide-linked vascular responses
- Helps maintain inflammatory and oxidative balance
Microcirculation & scalp support
β-Caryophyllene
CB2 / NRF2
- CB2-linked signaling support
- Supports Nrf2 antioxidant defense
- Helps maintain NF-κB and ROS balance
Immune & antioxidant balance
Limonene
System delivery
- Supports ingredient distribution across the stratum corneum
- Complements the Morphagen™ ingredient system
- Supports a refreshed scalp sensory profile
System delivery support
01 · Hair Follicle Signal Triggers & ROS
Science for healthier hair
Exposome Factors
External and internal factors that increase ROS and stress the hair follicle.
Pollution
UV radiation
Smoking
Diet
Stress
Poor sleep
Temperature fluctuations
Inflammation
Hormonal changes
Metabolic imbalance
ROS
Inhibits hair follicle
02 · Follicle Signaling & Hair-Cycle Support
Science for healthier hair
Bio-Responsive Hair Follicle Signaling
Morphagen™ helps activate key pathways for hair-cycle support.
EpidermisMorphagen™Sensory nervesPatched (PTCH)Smoothened(SMO) ↑Sonic hedgehog
(SHH) ↑GLI ↑Cyclin D ↑Hair Cycle ↑OR2AT4 ↑G-protein ↑cAMP ↑Pogostemon cablin
Patchouli alcohol
Scroll to explore the pathway
A&S Morphagen™
Science for healthier hair
A&S Morphagen™ · Visible Hair Benefit Profile
Plant science. Advanced hair care.
Healthier-looking hair growth
Helps support visible hair growth and vitality.
Fuller-looking hair
Supports a denser, more voluminous-looking appearance.
Hair cycle support
Helps support a healthy active hair cycle.
Follicle vitality
Supports follicle stem-cell-associated renewal signaling.
Scalp balance
Helps support balanced scalp comfort and resilience.
Reduced visible thinning
Helps improve the look of miniaturization-related thinning.
ChromgenTM
Supports Hair Follicle Pigmentation
and Color Vitality
SCIENCE-INSPIRED BY NATURE
ChromgenTM
COMPANY-DEVELOPED
PROPRIETARY BIO-RESPONSIVE INGREDIENT
NATURE
ACTIVATES
POTENTIAL
Four Aroma Bio-Responsive Ingredients in ChromgenTM
Eugenol
Spicy • Activating
Clove Oil
Spicy • Stimulating
Lotus
Floral • Balancing
Palmitic Acid
Methyl Ester
Lipidic • Supporting
(NELUMBO NUCIFERA)
C10H12O2
Major component:
Eugenol
C10H12O2
C15H10O6
C17H34O2
ChromgenTM Supports:
Supports Wnt / β-catenin activity
Supports melanoblast / MSC / FMC signaling
Helps elevate α-MSH / MC1R / cAMP response
Supports MITF-associated melanogenesis
Supports tyrosinase / tyrosine pathway
Promotes melanin-associated
hair follicle pigmentation
NATURAL
INSIGHTS
FOR VIBRANT
TOMORROW
ChromgenTM
Supports Visible Benefits
SCIENCE-INSPIRED BY NATURE
Healthier-Looking Hair Color
Helps support visible pigment
vitality and tone.
Hair Pigmentation Support
Supports melanin-associated
hair follicle pigmentation.
Color Vitality
Supports a darker-looking,
more vivid hair appearance.
Follicular Melanocyte Support
Helps support pigment-cell-
associated renewal signaling.
Melanin Biosynthesis
Supports melanin production
pathways.
Reduced Visible Dullness /
Early Gray Appearance
Helps improve the appearance of pigment loss.
Exposome Factors
Stress /
neurochemical
surge
Oxidative
stress / H2O2
accumulation
Nutritional
deficiencies
(B12, D3, Cu,
Fe, Zn)
Hormonal /
thyroid
dysregulation
Autoimmune /
chronic
inflammatory
responses
UV
radiation
Air pollution /
particulate matter
(PM2,5)
Chemical dyes /
harsh hair
products
Tobacco smoke /
vaping
Sleep /
circadian
disruption
ROS
inhibits
Hair Follicle
(Pigment Unit)
Melanoblast
Wnt / β-catenin
Melanocyte stem cell (MSC)
Follicular melanocyte (FMC)
α-MSH
MC1R
cAMP
MITF
Tyrosinase
Tyrosine
Melanin
Hair Follicle Pigmentation
Primary Cilia
Wnt signaling occurs
at the primary cilium
of melanocyte
lineage cells.
ChromgenTM
supports
secretion /
signaling
stimulates
secretion /
signaling
ChromgenTM
Proprietary
bio-responsive
ingredient complex
Healthier Hair Color.
Stronger Pigment Vitality.
Supports melanin-associated hair follicle
pigmentation and healthier pigment cycling.